Source: http://www.thehollywoodgossip.com/2013/04/melissa-gilbert-and-timothy-busfield-married/
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Thursday, April 25, 2013
Google's Got A Problem. Search Ads Aren't Just For Search Engines Anymore
Search advertising became such a popular and lucrative juggernaut because it offered businesses the ability to reach and persuade people with true purchase intent. But now keyword targeting is available on Twitter and Facebook, which could loosen Google's stranglehold on ads that convince us what to buy.Source: http://feedproxy.google.com/~r/Techcrunch/~3/YTCJhJ7XOi4/
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'Toggle switch' to burn fat identified
Apr. 23, 2013 ? For a long time, scientists have dreamt of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten a step closer to this goal: They decoded a "toggle switch" in mice which can significantly stimulate fat burning.
The results are now being presented in the journal Nature Communications.
Many people not only in industrialized nations struggle with excess weight -- but all fat is not alike. "Love handles" in particular contain troublesome white fat cells which store excess food. Brown fat cells are the exact opposite: they burn excess energy as the desirable "heaters" of the body. Scientists at the University of Bonn working with Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology, have spent years using animal models to explore how the undesirable white fat can be converted into sought-after brown fat. "In this way, excess pounds may be able to simply be melted away and obesity combated," says Prof. Pfeifer.
A kind of "trigger switch" spurs fat burning
The researchers have now decoded a "microRNA switch" in mice which is important for brown fat cells. Micro-RNAs are located in the genome of cells and very quickly and efficiently regulate gene activity. The researchers studied a specific microRNA: microRNA 155. The gene regulator micro-RNA 155 inhibits a certain transcription factor, that controls brown fat cell function. Surprisingly, Prof. Pfeifer and his team found that the transcription factor also regulates the levels microRNA 155 establishing a tight feed-back loop that works like a toggle switch: When the microRNA is highly expressed brown fat cell differentiation is blocked; conversely, if the transcription factor wins the upper hand, brown fat is produced at an increased level and this in turn boosts fat burning in the body.
In knockout mice, the gene for Micro-RNA 155 was silent
The researchers at Bonn University and their colleagues from the Federal Institute of Drugs and Medical Devices (BfArM) and from the University of Regensburg worked with so-called transgenic and knockout mice in whom the gene for micro-RNA 155 was either increased or silenced. "The mechanism was already set in motion when the micro-RNA 155 was only halved in the mice," reports lead author Yong Chen, graduate student of the NRW International Graduate School BIOTECH-PHARMA. The mice then had significantly more brown fat cells available than did the control gro up -- and had even converted white fat cells into brown fat cells.
Clues to the causes of lipid metabolism diseases
The micro-RNA functions as an antagonist to the brown fat cells. "As long as enough micro-RNA 155 is present, the production of brown fat cells is blocked," says Chen. Only if it falls below a certain proportion does this brake let up; the blueprint for brown fat can be read and implemented by the cell -- the desired fat burners can develop. These findings help scientists better understand the causes of lipid metabolism diseases.
Hope for new therapies against obesity
The scientists at the University of Bonn see in their results a potential starting point for drugs to combat obesity. The researchers have clues to the fact that the results, if anything, can be transferred from mice to humans. Thus, for example, researchers in Leipzig found increased levels of micro-RNA 155 in significantly overweight patients. This corresponds to findings from animal models: A lot of micro-RNA 155 is associated with reduced fat burning. "However, we are still in the basic research stage," says Prof. Pfeifer. The path to suitable drugs is still a long one.
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Story Source:
The above story is reprinted from materials provided by Universit?t Bonn, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Yong Chen, Franziska Siegel, Stefanie Kipschull, Bodo Haas, Holger Fr?hlich, Gunter Meister, Alexander Pfeifer. miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nature Communications, 2013; 4: 1769 DOI: 10.1038/ncomms2742
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/2asP3gl0lPk/130423110742.htm
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Teen years may be critical in later stroke risk
Apr. 24, 2013 ? The teenage years may be a key period of vulnerability related to living in the "stroke belt" when it comes to future stroke risk, according to a new study published in the April 24, 2013, online issue of Neurology?, the medical journal of the American Academy of Neurology.
More people have strokes and die of strokes in the southeastern area known as the stroke belt than in the rest of the United States. So far, research has shown that only part of the difference can be explained by traditional risk factors such as diabetes and high blood pressure. Previous studies have shown that people who are born in the stroke belt but no longer lived there in adulthood continue to have a higher risk of stroke, along with people who were born outside the stroke belt but lived there in adulthood.
The current study looked at how long people lived in the stroke belt and their ages when they lived there throughout life to see if any age period was most critical in influencing future stroke risk.
Data came from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national random sample of the general population with more people selected from the stroke belt. The study involved 24,544 people with an average age of 65 who had never had a stroke at the start of the study, with 57 percent currently living in the stroke belt and 43 percent from the rest of the country. The study tracked each person's moves from birth to present, with some people moving into or out of the stroke belt. The participants were then followed for an average of 5.8 years. During that time, 615 people had a first stroke.
After adjusting for stroke risk factors, only living in the stroke belt during the teenage years was associated with a higher risk of stroke. People who spent their teenage years in the stroke belt were 17 percent more likely to have a stroke in later years than people who did not spend their teenage years in the stroke belt. Across all age periods, living in the stroke belt increased the risk about two-fold for African-Americans compared to Caucasians.
"This study suggests that strategies to prevent stroke need to start early in life," said study author Virginia J. Howard, PhD, of the School of Public Health, University of Alabama at Birmingham and a member of the American Academy of Neurology. "Many social and behavioral risk factors, such as smoking, are set in place during the teenage years, and teens are more exposed to external influences and gain the knowledge to challenge or reaffirm their childhood habits and lifestyle."
The study was supported by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging.
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Story Source:
The above story is reprinted from materials provided by American Academy of Neurology.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Virginia J. Howard et al. Effect of duration and age at exposure to the Stroke Belt on incident stroke in adulthood. Neurology, 2013 DOI: 10.1212/WNL.0b013e3182904d59
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/X70Dgq8vmN4/130424161106.htm
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Wednesday, April 24, 2013
Facebook Acqhires Team From HTML5 Game Platform Spaceport.io, Which Will Keep Running
Spaceport.io has just announced that part of its team, but not its technology, is moving to Facebook, and the social network has confirmed the talent deal to me. But instead of shutting down, Spaceport.io will continue to operate its Adobe Air alternative under the direction of co-founder Peter Relan and the team from his incubator YouWeb that backed Spaceport.Source: http://feedproxy.google.com/~r/Techcrunch/~3/8IxZu8vJwFg/
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Product Review: Sunday Riley Prismasilk Eye Color in Sanders ...
I?ve already reviewed several Prismasilk Eye Colors from Sunday Riley (see my posts on?Lady Godiva?and Moon Dust), but I?m still finding other shades to love. Lately I?ve been wearing Sanders, a light brown with coppery shimmer.
I don?t know what ?Sanders? means, but I?m enjoying this color. It?s warmer than Lady Godiva, which is more of a light cocoa-taupe with silvery shimmer, but it?s just as versatile. It can be applied as a sheer wash or layered on with a denser brush for a richer appearance and, like Sunday Riley?s other eye shadows, it has a very fine, silky texture.
I?m still a complete amateur at taking ?swatch? photos, but this shot should give you a rough idea. (It actually looks a little too warm here; I tried!) It really is a shade that would flatter most skin tones.
Sanders lasts all day on my lids when I apply it over my usual primer (Urban Decay?s original Eyeshadow Primer Potion) and it doesn?t release any annoying ?fall-out? onto the area around my eyes.
All in all, a high-quality essential that will be getting plenty of use!
Sunday Riley Prismasilk Eye Colors ($26 each) are available at Bergdorf Goodman (you can reach the Sunday Riley counter manager Stacie at 212-872-8635), Barneys, the Sephora website, and Dermstore online.
Product source: I received this product as a gift with purchase when I shopped at Bergdorf Goodman?s Sunday Riley counter during a promotional event.
Images: photos by Tinsel Creation.
This entry was posted in Product Reviews and tagged eye shadow, sunday riley. Bookmark the permalink.Source: http://tinselcreation.com/2013/04/24/product-review-sunday-riley-prismasilk-eye-color-in-sanders/
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Lawyer: Palestinian hunger striker to end fast
JERUSALEM (AP) ? A Palestinian prisoner who refused food for months is expected to end his hunger strike on Tuesday after a deal was reached with Israeli authorities for his early release, his lawyer said.
Samer Issawi began refusing food in August to protest his re-arrest. His strike became a rallying cry for Palestinians who protested, sometimes violently, on his behalf, seeing the 33-year-old from Jerusalem as a symbol of their struggle. Israel was worried there would be wide unrest if anything happened to Issawi.
The prisoner issue is one of the most sensitive for Palestinians, many of whom have had a loved one behind bars. There are some 4,500 Palestinians in Israel jails for sentences ranging from throwing stones to killing civilians in deadly attacks.
Palestinians widely see the prisoners as heroes in the struggle for statehood while Israelis view them as terrorists.
Attorney Jawad Bulous said Israeli military prosecutors agreed on early Tuesday to release Issawi after he serves another eight months in prison, which would mean he would be released later this year. The lawyer said he expected the deal to be signed later in the day, after which Issawi will end his hunger strike.
In 2002, Issawi was sentenced to 26 years in prison for his role in a series of shooting attacks targeting police cars and students at Jerusalem's Hebrew University.
He was released from prison as part of a 2011 deal that freed hundreds of Palestinians ? many of them militants involved in deadly attacks ? in exchange for the release of an Israeli soldier held in Gaza. But soon after that, Issawi violated the conditions of his release and was arrested again.
Issawi had been hospitalized in recent weeks as his weight plummeted and his health deteriorated. To pressure Israeli authorities to come to a deal, Issawi gambled with his life, refusing infusions of vitamins and minerals, leading doctors to warn he was at risk of death, his attorney said.
"No doubt, this is a big victory for Samer," Bulous said. The hunger strike "forced the Israeli side to reverse their position."
Ayman Sharawneh, another Palestinian prisoner who was rearrested for violating his release conditions last year, went on a hunger strike until he was released in March in a deal that saw him exiled to Hamas-run Gaza Strip.
Sharawneh was arrested in 2002 for his involvement in a bombing in the southern Israeli town of Beersheba that injured 18 civilians, the attempted kidnapping of a soldier, and shooting at soldiers.
Source: http://news.yahoo.com/lawyer-palestinian-hunger-striker-end-fast-062601592.html
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