Source: http://www.thehollywoodgossip.com/2013/04/melissa-gilbert-and-timothy-busfield-married/
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Thursday, April 25, 2013
Google's Got A Problem. Search Ads Aren't Just For Search Engines Anymore
Search advertising became such a popular and lucrative juggernaut because it offered businesses the ability to reach and persuade people with true purchase intent. But now keyword targeting is available on Twitter and Facebook, which could loosen Google's stranglehold on ads that convince us what to buy.Source: http://feedproxy.google.com/~r/Techcrunch/~3/YTCJhJ7XOi4/
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'Toggle switch' to burn fat identified
Apr. 23, 2013 ? For a long time, scientists have dreamt of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten a step closer to this goal: They decoded a "toggle switch" in mice which can significantly stimulate fat burning.
The results are now being presented in the journal Nature Communications.
Many people not only in industrialized nations struggle with excess weight -- but all fat is not alike. "Love handles" in particular contain troublesome white fat cells which store excess food. Brown fat cells are the exact opposite: they burn excess energy as the desirable "heaters" of the body. Scientists at the University of Bonn working with Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology, have spent years using animal models to explore how the undesirable white fat can be converted into sought-after brown fat. "In this way, excess pounds may be able to simply be melted away and obesity combated," says Prof. Pfeifer.
A kind of "trigger switch" spurs fat burning
The researchers have now decoded a "microRNA switch" in mice which is important for brown fat cells. Micro-RNAs are located in the genome of cells and very quickly and efficiently regulate gene activity. The researchers studied a specific microRNA: microRNA 155. The gene regulator micro-RNA 155 inhibits a certain transcription factor, that controls brown fat cell function. Surprisingly, Prof. Pfeifer and his team found that the transcription factor also regulates the levels microRNA 155 establishing a tight feed-back loop that works like a toggle switch: When the microRNA is highly expressed brown fat cell differentiation is blocked; conversely, if the transcription factor wins the upper hand, brown fat is produced at an increased level and this in turn boosts fat burning in the body.
In knockout mice, the gene for Micro-RNA 155 was silent
The researchers at Bonn University and their colleagues from the Federal Institute of Drugs and Medical Devices (BfArM) and from the University of Regensburg worked with so-called transgenic and knockout mice in whom the gene for micro-RNA 155 was either increased or silenced. "The mechanism was already set in motion when the micro-RNA 155 was only halved in the mice," reports lead author Yong Chen, graduate student of the NRW International Graduate School BIOTECH-PHARMA. The mice then had significantly more brown fat cells available than did the control gro up -- and had even converted white fat cells into brown fat cells.
Clues to the causes of lipid metabolism diseases
The micro-RNA functions as an antagonist to the brown fat cells. "As long as enough micro-RNA 155 is present, the production of brown fat cells is blocked," says Chen. Only if it falls below a certain proportion does this brake let up; the blueprint for brown fat can be read and implemented by the cell -- the desired fat burners can develop. These findings help scientists better understand the causes of lipid metabolism diseases.
Hope for new therapies against obesity
The scientists at the University of Bonn see in their results a potential starting point for drugs to combat obesity. The researchers have clues to the fact that the results, if anything, can be transferred from mice to humans. Thus, for example, researchers in Leipzig found increased levels of micro-RNA 155 in significantly overweight patients. This corresponds to findings from animal models: A lot of micro-RNA 155 is associated with reduced fat burning. "However, we are still in the basic research stage," says Prof. Pfeifer. The path to suitable drugs is still a long one.
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The above story is reprinted from materials provided by Universit?t Bonn, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Yong Chen, Franziska Siegel, Stefanie Kipschull, Bodo Haas, Holger Fr?hlich, Gunter Meister, Alexander Pfeifer. miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nature Communications, 2013; 4: 1769 DOI: 10.1038/ncomms2742
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/2asP3gl0lPk/130423110742.htm
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Teen years may be critical in later stroke risk
Apr. 24, 2013 ? The teenage years may be a key period of vulnerability related to living in the "stroke belt" when it comes to future stroke risk, according to a new study published in the April 24, 2013, online issue of Neurology?, the medical journal of the American Academy of Neurology.
More people have strokes and die of strokes in the southeastern area known as the stroke belt than in the rest of the United States. So far, research has shown that only part of the difference can be explained by traditional risk factors such as diabetes and high blood pressure. Previous studies have shown that people who are born in the stroke belt but no longer lived there in adulthood continue to have a higher risk of stroke, along with people who were born outside the stroke belt but lived there in adulthood.
The current study looked at how long people lived in the stroke belt and their ages when they lived there throughout life to see if any age period was most critical in influencing future stroke risk.
Data came from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national random sample of the general population with more people selected from the stroke belt. The study involved 24,544 people with an average age of 65 who had never had a stroke at the start of the study, with 57 percent currently living in the stroke belt and 43 percent from the rest of the country. The study tracked each person's moves from birth to present, with some people moving into or out of the stroke belt. The participants were then followed for an average of 5.8 years. During that time, 615 people had a first stroke.
After adjusting for stroke risk factors, only living in the stroke belt during the teenage years was associated with a higher risk of stroke. People who spent their teenage years in the stroke belt were 17 percent more likely to have a stroke in later years than people who did not spend their teenage years in the stroke belt. Across all age periods, living in the stroke belt increased the risk about two-fold for African-Americans compared to Caucasians.
"This study suggests that strategies to prevent stroke need to start early in life," said study author Virginia J. Howard, PhD, of the School of Public Health, University of Alabama at Birmingham and a member of the American Academy of Neurology. "Many social and behavioral risk factors, such as smoking, are set in place during the teenage years, and teens are more exposed to external influences and gain the knowledge to challenge or reaffirm their childhood habits and lifestyle."
The study was supported by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging.
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The above story is reprinted from materials provided by American Academy of Neurology.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Virginia J. Howard et al. Effect of duration and age at exposure to the Stroke Belt on incident stroke in adulthood. Neurology, 2013 DOI: 10.1212/WNL.0b013e3182904d59
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/X70Dgq8vmN4/130424161106.htm
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Wednesday, April 24, 2013
Facebook Acqhires Team From HTML5 Game Platform Spaceport.io, Which Will Keep Running
Spaceport.io has just announced that part of its team, but not its technology, is moving to Facebook, and the social network has confirmed the talent deal to me. But instead of shutting down, Spaceport.io will continue to operate its Adobe Air alternative under the direction of co-founder Peter Relan and the team from his incubator YouWeb that backed Spaceport.Source: http://feedproxy.google.com/~r/Techcrunch/~3/8IxZu8vJwFg/
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Product Review: Sunday Riley Prismasilk Eye Color in Sanders ...
I?ve already reviewed several Prismasilk Eye Colors from Sunday Riley (see my posts on?Lady Godiva?and Moon Dust), but I?m still finding other shades to love. Lately I?ve been wearing Sanders, a light brown with coppery shimmer.
I don?t know what ?Sanders? means, but I?m enjoying this color. It?s warmer than Lady Godiva, which is more of a light cocoa-taupe with silvery shimmer, but it?s just as versatile. It can be applied as a sheer wash or layered on with a denser brush for a richer appearance and, like Sunday Riley?s other eye shadows, it has a very fine, silky texture.
I?m still a complete amateur at taking ?swatch? photos, but this shot should give you a rough idea. (It actually looks a little too warm here; I tried!) It really is a shade that would flatter most skin tones.
Sanders lasts all day on my lids when I apply it over my usual primer (Urban Decay?s original Eyeshadow Primer Potion) and it doesn?t release any annoying ?fall-out? onto the area around my eyes.
All in all, a high-quality essential that will be getting plenty of use!
Sunday Riley Prismasilk Eye Colors ($26 each) are available at Bergdorf Goodman (you can reach the Sunday Riley counter manager Stacie at 212-872-8635), Barneys, the Sephora website, and Dermstore online.
Product source: I received this product as a gift with purchase when I shopped at Bergdorf Goodman?s Sunday Riley counter during a promotional event.
Images: photos by Tinsel Creation.
This entry was posted in Product Reviews and tagged eye shadow, sunday riley. Bookmark the permalink.Source: http://tinselcreation.com/2013/04/24/product-review-sunday-riley-prismasilk-eye-color-in-sanders/
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Lawyer: Palestinian hunger striker to end fast
JERUSALEM (AP) ? A Palestinian prisoner who refused food for months is expected to end his hunger strike on Tuesday after a deal was reached with Israeli authorities for his early release, his lawyer said.
Samer Issawi began refusing food in August to protest his re-arrest. His strike became a rallying cry for Palestinians who protested, sometimes violently, on his behalf, seeing the 33-year-old from Jerusalem as a symbol of their struggle. Israel was worried there would be wide unrest if anything happened to Issawi.
The prisoner issue is one of the most sensitive for Palestinians, many of whom have had a loved one behind bars. There are some 4,500 Palestinians in Israel jails for sentences ranging from throwing stones to killing civilians in deadly attacks.
Palestinians widely see the prisoners as heroes in the struggle for statehood while Israelis view them as terrorists.
Attorney Jawad Bulous said Israeli military prosecutors agreed on early Tuesday to release Issawi after he serves another eight months in prison, which would mean he would be released later this year. The lawyer said he expected the deal to be signed later in the day, after which Issawi will end his hunger strike.
In 2002, Issawi was sentenced to 26 years in prison for his role in a series of shooting attacks targeting police cars and students at Jerusalem's Hebrew University.
He was released from prison as part of a 2011 deal that freed hundreds of Palestinians ? many of them militants involved in deadly attacks ? in exchange for the release of an Israeli soldier held in Gaza. But soon after that, Issawi violated the conditions of his release and was arrested again.
Issawi had been hospitalized in recent weeks as his weight plummeted and his health deteriorated. To pressure Israeli authorities to come to a deal, Issawi gambled with his life, refusing infusions of vitamins and minerals, leading doctors to warn he was at risk of death, his attorney said.
"No doubt, this is a big victory for Samer," Bulous said. The hunger strike "forced the Israeli side to reverse their position."
Ayman Sharawneh, another Palestinian prisoner who was rearrested for violating his release conditions last year, went on a hunger strike until he was released in March in a deal that saw him exiled to Hamas-run Gaza Strip.
Sharawneh was arrested in 2002 for his involvement in a bombing in the southern Israeli town of Beersheba that injured 18 civilians, the attempted kidnapping of a soldier, and shooting at soldiers.
Source: http://news.yahoo.com/lawyer-palestinian-hunger-striker-end-fast-062601592.html
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Anti-terror sting snags Chicago-area teen
CHICAGO (AP) ? It had the trappings of an actual extremist website: Photos of gun-toting fighters and a flowery exhortation to, "Come and join your lion brothers ... fighting under the true banner of Islam."
Except, it wasn't what it seemed.
It was a sham site constructed and controlled by the FBI with the aim of snaring terrorist wannabes in the virtual world before they could carry out real-world harm.
Abdella Ahmad Tounisi, 18, was arrested last week on a terrorism charge stemming from the sting operation. He made a brief court appearance Tuesday in federal court in Chicago.
The American-born man from Aurora is accused of seeking to join al-Qaida-affiliated Jabhat al-Nusrah, which is fighting the Syrian Bashar Assad regime in a bloody civil war.
Critics say the use of such sites raises questions about whether authorities are overreaching, wooing impressionable youth to contemplate crimes that otherwise wouldn't cross their minds.
"These sites can end up creating crimes," said Phil Turner, a former federal prosecutor-turned-defense attorney in Chicago. "Real terrorists don't need to go to a website for contacts. They have real contacts."
Federal investigators, he added, sometimes favor Internet stings because they are less costly and labor intensive than traditional stakeouts.
"From your office computer, you can get millions of cases like this ? sucking people in," he said. "But it diverts are attention from the real terrorists."
Others disagree.
Mike Fagel, a Chicago-based security consultant, asks who, if given the chance, wouldn't have wanted to catch the Boston Marathon bombing suspects plotting online before they successfully carried out an attack.
"These are valid tools," Fagel said. "As an emergency planner guy, if I can prevent something from happening, I don't have to worry about response and recover."
And given how the terrorism is evolving, the Internet is a logical place to hunt for potential attackers, he added.
"We are seeing younger and younger assailants," he said. "And they operate on the Internet."
Authorities have also noted that it's not visiting such sites or fantasizing about acts of terrorism that's the crime. The crime is acting on those fantasies and taking specific steps make it happen.
Tounisi's steps, authorities say, included trying to board a plane in Chicago.
He was arrested at O'Hare International Airport Friday as he prepared to start the first leg of a trip that authorities allege he hoped would hook him up with an al-Qaida-affiliated group in Syria.
Tounisi is charged with one count of attempting to provide material support to foreign terrorists. If convicted, he faces a maximum 15-year prison term. His attorney, Molly Armour, declined comment on Tuesday.
Despite his orange jail garb and shackled ankles, Tounisi looked younger than his 18 years at his court appearance, during which a judge delayed a decision on bond. Later, he cast a worried look at his parents sitting nearby on a spectators' bench.
It was only months ago that he is accused of coming across the website.
What he saw written across the home page, allegedly signaled to Tounisi that he had found what he'd been looking for. "A Call for Jihad in Syria," it said in both English and Arabic.
The site not only offered to hook up would-be fighters with terrorists, it even offered advice on how users could cover their Internet tracks from law enforcement, according to a detailed federal complaint.
"We are aware of (non-Muslims') tricks and the behavior of their unjust governments," the site says.
As some point, Tounisi allegedly took the bait.
In an April 1, 2013, email to an FBI agent posing as a terrorist recruiter, Tounisi comes across as earnest and frank, including about how some might see his youth and 5-foot-6 stature as an impediment.
"Concerning my fighting skills, to be honest, I do not have any," he allegedly wrote. "I'm very small ... physically but I pray to Allah that he makes me successful."
Not to worry, the FBI responds encouragingly in an email back to Tounisi.
"We have trust in Allah that you will fight and do your Jihad as a true (believer)," it says.
While he is accused of taking steps to further his desire to fight in Syria, his online searches also seem to convey some concern about legal implications. According to the complaint, for instance, he searched the phrases "providing material support what does it mean" and "Terrorism Act 2000."
Joan Hyde, a spokesman for the FBI in Chicago, declined any comment Tuesday, saying the agency doesn't comment on ongoing cases.
The federal complaint suggests, however, that federal authorities don't want to hang their whole case on allegations Tounisi acted on what he read on the site.
It also alleges he was a close friend of Adel Daoud, a Chicago-area teen arrested last year on charges he tried to detonate a device he thought was a bomb outside a downtown bar. The complaint contends the two friends even discussed potential targets Daoud could hit.
Federal authorities don't accuse Tounisi of participating in the alleged attack planned by Daoud. But broaching his relationship in such detail may help prosecutors counter any future claim Tounisi stumbled onto the site and into the alleged crime by sheer naivet?.
Ironically, Tounisi allegedly opted out of Daoud's plot because he sensed ? in that instance, one year before his own arrest ? that something didn't feel right: He had concluded, according to the complaint, that Daoud's key contact may have been working for law enforcement.
In filings after Daoud's arrest, prosecutors acknowledged that the contact was, in fact, an FBI informant.
___
Follow Michael Tarm at www.twitter.com/mtarm
Source: http://news.yahoo.com/chicago-area-teen-latest-snared-website-traps-195908623.html
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Suspect in Canada terror plot rambles in cout appearance
TORONTO (AP) ? A man accused of plotting with al-Qaida members in Iran to derail a train in Canada gave a rambling statement in a Toronto court Wednesday and appeared to be saying he does not recognize its jurisdiction.
Law enforcement officials in the U.S. said the target was a train that runs between New York City and Canada. Canadian investigators say Chiheb Esseghaier, 30, and Raed Jaser, 35, received guidance from members of al-Qaida in Iran. Iranian government officials have said the government had nothing to do with the plot.
"My comment is the following because all of those conclusions were taken out based on criminal code and all of us know that this criminal code is not a holy book," Esseghaier said at the hearing Wednesday. "We cannot rely on the conclusions taken out from these judgments."
The judge told him to "save that for another court," and take the advice of his lawyers. He was given a May 23 court date.
Charges against the two men in Canada include conspiring to carry out an attack and murder people in association with a terrorist group. Police ? tipped off by an imam worried by the behavior of one of the suspects ? said it was the first known attack planned by al-Qaida in Canada. The two could be sentenced to life in prison if convicted.
In a brief court appearance in Montreal on Tuesday, Esseghaier declined to be represented by a court-appointed lawyer. He made a brief statement in French in which he rejected the allegations against him.
Esseghaier, who was arrested Monday afternoon at a McDonald's restaurant in the train station, was later flown to Toronto for Wednesday's appearance in the city where his trial will take place.
Jaser also appeared in court Tuesday in Toronto and also did not enter a plea. He was given a new court date of May 23. The court granted a request by his lawyer, John Norris, for a publication ban on future evidence and testimony.
The case has raised questions about the extent of Shiite-led Iran's relationship with al-Qaida, a predominantly Sunni Arab terrorist network. It also renewed attention on Iran's complicated history with the terror group, which ranges from outright hostility to alliances of convenience and even overtures by Tehran to assist Washington after the Sept. 11, 2001, attacks on the United States.
Law officials in New York with knowledge of the investigation told The Associated Press the attack was to take place on the Canadian side of the border. They are not authorized to discuss the investigation and spoke only on condition of anonymity.
Jaser's lawyer said on Tuesday that his client questioned the timing of the arrests, pointing to ongoing debates in the Canadian Parliament over a new anti-terrorism law that would expand the powers of police and intelligence agencies.
Norris speaking outside the court said his client is "in a state of shock and disbelief."
He said his client would "defend himself vigorously" against the accusations, and noted Jaser was a permanent resident of Canada who has lived there for 20 years. Norris refused to say where Jaser was from, saying that revealing his nationality in the current climate amounted to demonizing him.
Canadian police have declined to release the men's nationalities, saying only they had been in Canada a "significant amount of time." But a London-based newspaper Al Arab reported Wednesday, citing unnamed sources in the Gulf, that Jaser is a Jordanian passport holder with full name Raed Jaser Ibrahim Amouri, who had visited the UAE several times and most recently in September 2011. The newspaper reported that the suspect also visited other Gulf countries including Qatar and Saudi Arabia. It was not possible to independently confirm the report.
Esseghaier's, in a profile on a university department website ? which has since been removed ? says he was born in Tunis, Tunisia.
Muhammad Robert Heft, president of the P4E Support Group Inc., a non-profit organization that provides support to Muslims in Canada, said Jaser's father Mohammad Jaser came to him several times citing concerns about the radicalization of his son. The discussions took place between 2010 and 2011, while the father was living in a basement apartment in Heft's home in Markham, Ontario. The pair took up accommodation there while awaiting surgery for Jaser's younger brother, who had been in a serious car accident, because the apartment didn't have stairs.
"He came to me about his son saying he how concerned he was getting about the rigidness of his son and his interpretation of Islam. He was becoming self-righteous, becoming pushy, pushing his views on how much they (his family) should be practicing as a Muslim," said Heft.
"His son was becoming overzealous and intolerant in his understanding of the religion," he said. "Those are the telltale signs that can lead into the radicalization process."
The investigation surrounding the planned attack was part of a cross-border operation involving Canadian law enforcement agencies, the FBI and the U.S. Department of Homeland Security. Canadian police said the men never got close to carrying out the attack.
The warning first came from an imam in Toronto, who in turn was tipped off by suspicious behavior on the part of one of the suspect.
___
Associated Press writers Benjamin Shingler in Montreal, Tom Hays and Jennifer Peltz in New York, Kimberly Dozier in Washington and Brian Murphy in the United Arab Emirates contributed to this story.
Source: http://news.yahoo.com/suspect-canada-terror-plot-denies-charges-220238197.html
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Yum profit beats even as bird flu batters China sales
(Reuters) - KFC parent Yum Brands Inc
Sales at established restaurants in China fell 20 percent during the first quarter and Yum warned that fears surrounding a bird flu outbreak there were continuing to depress sales already struggling to recover from a previous food safety scare.
The fast-food operator reaps more than half of its overall sales in China, where most of its nearly 5,300 restaurants are KFCs.
The drop in sales was a major contributor to the first quarter's profit decline.
Net income fell to $337 million, or 72 cents per share, from $458 million, or 96 cents per share, a year earlier.
Excluding items, first-quarter earnings were 70 cents per share, 10 cents better than the average of analysts estimates compiled by Thomson Reuters I/B/E/S.
Yum shares were up $4.18 at $68.33 in extended trading.
(Reporting by Lisa Baertlein in Los Angeles. Editing by Andre Grenon)
Source: http://news.yahoo.com/yum-profit-beats-even-bird-flu-batters-china-215004553--finance.html
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Tuesday, April 23, 2013
Epigenetic changes shed light on biological mechanism of autism
Apr. 23, 2013 ? Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits.
The study, published in Molecular Psychiatry, is the largest of its kind and may shed light on the biological mechanism by which environmental influences regulate the activity of certain genes and in turn contribute to the development of ASD and related behaviour traits.
ASD affects approximately 1 in 100 people in the UK and involves a spectrum of disorders which manifest themselves differently in different people. People with ASD have varying levels of impairment across three common areas: deficits in social interactions and understanding, repetitive behaviour and interests, and impairments in language and communication development.
Evidence from twin studies shows there is a strong genetic component to ASD and previous studies suggest that genes that direct brain development may be involved in the disorder. In approximately 70% of cases, when one identical twin has ASD, so does the other. However, in 30% of cases, identical twins differ for ASD. Because identical twins share the same genetic code, this suggests non-genetic, or epigenetic, factors may be involved.
Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence -- they are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.
The researchers studied an epigenetic mechanism called DNA methylation. DNA methylation acts to block the genetic sequences that drive gene expression, silencing gene activity. They examined DNA methylation at over 27,000 sites across the genome using samples taken from 50 identical twin pairs (100 individuals) from the UK Medical Research Council (MRC) funded Twins Early Development Study (TEDS): 34 pairs who differed for ASD or autism related behaviour traits, 5 pairs where both twins have ASD, and 11 healthy twin pairs.
Dr Chloe Wong, first author of the study from King's College London's Institute of Psychiatry, says: "We've identified distinctive patterns of DNA methylation associated with both autism diagnosis and related behaviour traits, and increasing severity of symptoms. Our findings give us an insight into the biological mechanism mediating the interaction between gene and environment in autism spectrum disorder."
DNA methylation at some genetic sites was consistently altered for all individuals with ASD, and differences at other sites were specific to certain symptom groups. The number of DNA methylation sites across the genome was also linked to the severity of autism symptoms suggesting a quantitative relationship between the two. Additionally, some of the differences in DNA methylation markers were located in genetic regions that previous research has associated with early brain development and ASD.
Professor Jonathan Mill, lead author of the paper from King's College London's Institute of Psychiatry and the University of Exeter, says: "Research into the intersection between genetic and environmental influences is crucial because risky environmental conditions can sometimes be avoided or changed. Epigenetic changes are potentially reversible, so our next step is to embark on larger studies to see whether we can identify key epigenetic changes common to the majority of people with autism to help us develop possible therapeutic interventions."
Dr Alycia Halladay, Senior Director of Environmental and Clinical Sciences from Autism Speaks who funded the research, says: "This is the first large-scale study to take a whole genome approach to studying epigenetic influences in twins who are genetically identical but have different symptoms. These findings open the door to future discoveries in the role of epigenetics -- in addition to genetics -- in the development of autism symptoms."
The study was funded by Autism Speaks, Medical Research Council UK (MRC) and the Brain and Behavior Research Foundation (NARSAD). The twins were selected from the Twins Early Development Study (TEDS) which is funded by the MRC with additional support from the US National Institutes of Health.
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The above story is reprinted from materials provided by King's College London.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- C C Y Wong, E L Meaburn, A Ronald, T S Price, A R Jeffries, L C Schalkwyk, R Plomin, J Mill. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2013.41
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/5SSPuYtQGZA/130423091113.htm
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This Week in Small Business: Apple, Gold and Cupcakes - NYTimes ...
Dashboard
A weekly roundup of small-business developments.
What?s affecting me, my clients and other small-business owners this week.
Must Reads
The argument for austerity takes a big hit, and the two economists at the center of the debate respond. Muhammad Yunus, the founder of the Grameen Bank and a recipient of the Congressional Gold Medal in recognition of his ?efforts to combat global poverty,? discusses lending without collateral and how business ideas are generated.
Boston: Reddit on the Case
Michael Sivy explains what the Boston bombing means for the economy and the stock market. There are many stories of businesses stepping up to help. The calamity reveals the value of social media, and an entrepreneur beats the conspiracy-theory ?kooks? at their own game. Reddit readers did not solve the bombing, but entrepreneurs did introduce EvidenceUpload.org to aid the investigation. Boston restaurants rallied to the cause.
The Economy: Apple, Gold and Cupcakes
Apple?s stock price falls. The price of gold crashes. And so does the market for expensive cupcakes. Rising costs put the squeeze on builder confidence in April. A Kauffman Foundation report finds that entrepreneurial activity declined in 2012 and that millennials are the least entrepreneurial generation. Port traffic in the Los Angeles area decreased. But conditions in the New York metropolitan (pdf) region improved, and housing starts and industrial production moved up. Crucial measures showed low inflation in March and the Federal Reserve reported moderate growth across the country. Paul Ryan says the G.O.P. has no plans to create a budget-deal panel with Senate Democrats. Twelve million Americans say they believe lizard people run the country.
Start-Up: The Strangest Start-Up
CorruptTour may be the strangest start-up in travel. Steve Blank says the lean start-up ?changes everything? and teams up with Google to create a five-week course for entrepreneurs. A tiny news start-up wins a Pulitzer. John Stanfield says every start-up should be familiar with this tax term: 83b election. A teenager auctions off 10 percent of her future earnings to start a Web site. A peer-to-peer airport car rental start-up raises $5.5 million.
Ideas: Let It Rot
A gas station in Germany offers haircuts while filling the tank. Peter Thiel?s latest investments include better search and cellular nanotechnology. Here are 10 ideas in retailing from the last 12 months. Investments in clean energy hit a four-year low. Google?s first BufferBox appears in San Francisco. Will Knight says autonomous vehicles will remain a fantasy for years, and Icelanders make poisonous shark meat edible by letting it rot for six months.
Management: Looking Sharp
These YouTube videos will teach you how to look sharp. Les McKeown says there are three things all great leaders know about themselves. If you want to know how to rocket to the top of an industry, you may want to consider the ?Macklemore Effect.? A new research report reveals the latest trends in corporate social responsibility. Cameron Herold shares the key to leading highly productive meetings, and Karol K. discusses the art of complaining about your business. Andrea Johnson explains how reversing the funnel increased sales by 14 percent for a sales-incentive company, and Alina Dizik says you should ask 10 questions before determining your target market.
People: Rude and Unprofessional
Erika Andersen explains how some companies lose their best employees at ?hello.? McDonald?s tries to change its image of ?rude, unprofessional employees.? A retail chain of arts-and-crafts stores in Oklahoma raises its full-time employees? minimum wage to $14 per hour. The chairman of US Airways sends a message to employees to explain why he earned $5.5 million in 2012. Here are 20 ways to manage a dysfunctional team. Allison Rice wonders if telecommuting will become a ?flash in the pan,? and Samuel Bacharach offers four reasons employees resist change. Here?s what to do about the bully in your workplace.
Around the Country: Colorado?s Entrepreneurs
Coming to New York: TechCrunch?s popular Disrupt conference and a $125,000 Business Innovation challenge. You can be one of three women to win a $3,000 grant for your work. A business-to-business networking expo is scheduled for Tucson this week, and the Downtown Sacramento Partnership is running a contest that will give the winner free rent for a year. Even though Philadelphia area economic activity is steady, the city?s mayor discusses selling assets to stave off bankruptcy. Philadelphia holds its annual Tech Week. Sales of small businesses are up in Tulsa, Okla., and a business tax cut is proposed in Texas. A campaign in Colorado spotlights entrepreneurs powering the state?s economy. These are the wealthiest subway stops in New York City.
Around the World: Disappointing Growth
Ford expects 40 percent of its sales will occur in China by the end of the decade. Ansuya Harjani says China?s disappointing economic growth (7.7 percent in the first quarter!) is ?leading to a loss of confidence.? Meanwhile, it is revealed that almost 2 percent of world trade comes from counterfeit Chinese goods. Elliott Auckland says storm clouds are gathering in Moscow. This is the global gross domestic product outlook in one huge map. S?o Paulo is named the most attractive Latin American city for investment. Britain?s jobless rate rises.
Red Tape: A Huge Train Wreck
Mark J. Kohler explains how incorporation in Delaware or Nevada can hurt you. This is what the ?Gang of Eight? immigration proposal would mean for entrepreneurs. A Louisiana senator wins an award for her dedication to small businesses. Senator Max Baucus says he fears President Obama?s health care overhaul is headed for a ?huge train wreck? ? but Ezra Klein isn?t buying it.
Taxes: More Audits
The Internal Revenue Service plans more audits of small-business owners, and secret data shows clusters of likely tax cheats in California, Texas, Georgia and Maryland. The government imposes an annual reporting cost of more than $180 billion on the American people, but these five charts will make you feel better about paying your taxes. Some business groups are backpedaling on tax reform, and these are the best and worst state tax systems for entrepreneurship and small businesses.
Cash Flow: Shipping Costs
Juergen Kneifel suggests terms business owners should know. Here are five ways to reduce shipping costs. Maryalene LaPonsie says there are three steps for small-business forecasting, and here is how to become a QuickBooks power user. Bradley Derringer believes accounting software improves your carbon footprint.
Finance: Cocaine and the Crisis
Citigroup?s profit rises 30 percent and Goldman Sachs earns $2.2 billion in the first quarter, but Bank of America?s revenue drops. Britain?s former drug czar says cocaine use by bankers caused the world financial crisis. The American Bankers Association offers tips to help small-business owners enhance their current banking relationships. A new survey shows bank risk managers are optimistic about small-business lending. Ashton Kutcher makes another investment.
Online: Design of the Year
A webinar on Tuesday will cover?best practices for landing pages. Chuck Hemann suggests five steps to build a digital analytics function. Eric Schmidt thinks the Facebook Home Android modification is ?fantastic.? Becky McCray names an almost-useful QR code. A simple government Web site earns the title of best design of the year.
Social Media: What?s a Facebook Fan Worth?
A study concludes that Facebook fans are worth $174.17 apiece. Jeff Bullas says social media is better ?than your granny.? One study shows small businesses are finding return on investment in social media (but struggling with Facebook), while another study concludes that social media is a bust for small businesses. Here are a few ways to measure social media marketing, and if you have just four minutes you can learn how to extend the reach of your e-mail. Twitter allows advertisers to target specific words used in tweets, and Paula Eder says retweeting adds traffic and saves time. Lucy Thornton suggests 41 marketing ideas for your Twitter account, including ?post a photo of the view out of your window right now.? Elaine Lindsay explains how to use Google Plus Hangouts to generate content.
Technology: Is Your Cash Register Obsolete?
Microsoft is reportedly developing a smartwatch, is ready to compete head-on with Amazon?s Web Services and makes more money off mobile handset sales than Google. But American teenagers still want an iPhone for their next smartphone. Gina Chon says to blame your mobile-phone company and the government for dropped calls. A report from Symantec finds small businesses are being battered by cybercrime. Chris Murphy says an app is not a mobile strategy. Google?s applications suffer a partial failure, a technical problem in Pennsylvania gives taxpayers a day?s reprieve and over 700 American Airlines flights are canceled after a computer system fails. Brian Patrick Eha wonders if Nebula One is reinventing cloud computing for businesses. Carla Turchetti asks whether your cash register is obsolete.
Tweet of the Week
@tompapa ? This is a good week to stay under the covers.
The Week?s Bests
Joe Weisenthal says everyone should be thrilled by the gold crash: ?The huge corpus of economic research, which has informed the U.S.?s efforts to stimulate the economy, is not a pile of garbage. You can do a lot without blowing things up, as the gold bugs claimed would happen. And more broadly, this represents a breaking of the fever, and perhaps a return to thinking that humans aren?t such a horrible disappointment.?
Leslie Young explains what a good boss should be doing: ?A good boss will not be smug and complacent with their performance. There is always room to grow and even bosses have something they can always do better. Being a leader entails a lot of responsibility and a good boss knows that they are accountable to the customers and the employees should something go wrong. Bad bosses are overconfident and think that they know everything there is to know. Good bosses think otherwise.?
This Week?s Question: Do you consider yourself a good boss?
Gene Marks owns the Marks Group, a Bala Cynwyd, Pa., consulting firm that helps clients with customer relationship management. You can follow him on Twitter.
Source: http://boss.blogs.nytimes.com/2013/04/22/this-week-in-small-business-apple-gold-and-cupcakes/
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Defense seeks new expert in Afghan killings case
JOINT BASE LEWIS-MCCHORD, Wash. (AP) ? Attorneys for the U.S. soldier accused of killing 16 Afghan civilians during a 2012 rampage have asked that a new psychiatric expert be appointed in the case.
Emma Scanlan, an attorney for Robert Bales, made the request during a hearing Tuesday at Joint Base Lewis-McChord south of Seattle.
Citing attorney-client privilege, Scanlan did not say why the request was made. The defense team provided its reasons to the judge ? but not prosecutors ? in a confidential court filing.
Prosecutors objected to the motion, saying it smacked of witness shopping.
Outside experts believe a key issue going forward will be to determine if Bales suffered from post-traumatic stress disorder. Bales served tours of duty in Iraq and Afghanistan.
A ruling on the defense team's request will be made later.
At Tuesday's hearing, attorneys also discussed which witnesses might be allowed to testify on Bales' behalf, should the case reach a sentencing phase.
"A lot of our witnesses that we want to testify in a potential penalty phase will be here, including Sgt. Bales' mother," Scanlan said. "She's a very important witness to who he was as a child and who he is a man."
Defense attorneys also asked for a consultant to be appointed to help them pick jurors. The judge said he would rule on that later.
The defense also requested the handwritten notes of the first Afghan government officials who viewed the crime scene.
The defense team has received an official report about those findings, but lawyers said the notes could yield information left out of the report. Prosecutors said they so far have been unable to obtain the notes from the Afghans. At the judge's request, they agreed to make another attempt through official channels.
"They took a lot of notes, and that's what we want to see," Major Greg Malson, one of Bales' attorney, said after the hearing.
Bales is to be court-martialed on premeditated murder and other charges in the attack on two villages in southern Afghanistan.
The Ohio native and father of two is accused of slaying mostly women and children during pre-dawn raids on March 11, 2012.
Bales, 39, has not entered a plea. The Army is seeking the death penalty. The U.S. military has not executed anyone since 1961.
The slayings last year drew such angry protests that the U.S. temporarily halted combat operations in Afghanistan, and it was three weeks before American investigators could reach the crime scenes.
Bales' defense team has said the government's case is incomplete.
During a previous preliminary hearing, prosecutors built a strong eyewitness case against the veteran soldier, with troops recounting how they saw Bales return to the base alone, covered in blood. One soldier testified that Bales woke him up in the middle of the night, saying he had just shot people at one village and that he was heading out again to attack another. The soldier said he didn't believe Bales and went back to sleep.
Afghan witnesses questioned via a video link from a forward operating base near Kandahar City described the horror of that night. A teenage boy recalled how the gunman kept firing as youths scrambled, yelling: "We are children! We are children!"
An Army criminal investigations command special agent testified earlier that Bales tested positive for steroids three days after the killings, and other soldiers testified that Bales had been drinking the evening of the massacre.
Source: http://news.yahoo.com/defense-seeks-expert-afghan-killings-case-181146832.html
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TechCrunch Giveaway: Last Two Free Tickets To Disrupt NY
TechCrunch Disrupt NY is right around the corner. Everything kicks off this weekend in New York with the Hackathon starting on Saturday and going through the night until Sunday afternoon. The main event kicks off next Monday, where expert speakers and guests will come together to talk with us about the latest in technology. The full agenda is here. Every week we have been giving away a chance to win a free ticket to Disrupt NY. We only have two free tickets left. These tickets will get the two winners into the conference, plus all of the after parties that follow including the screening of Shawn Fanning’s documentary on Napster, DOWNLOADED. To win a ticket all you have to do is follow the steps below. The giveaway will start now and end tomorrow at 12pm PT. Yes, that’s only one day, so be sure to act fast. 1) Become a fan of our TechCrunch Facebook Page: 2) Then do one of the following: - Retweet this post (making sure to include the #TCDisrupt hashtag) - Or leave us a comment below telling us why you want to come Please only tweet the message once or you will be disqualified. We will make sure you follow the steps above and choose our winners tomorrow. Anyone in the world is eligible. Please note each ticket is for one person only and does not include airfare or hotel. Our sponsors help make Disrupt happen. If you are interested in learning more about sponsorship opportunities, please contact our sponsorship team here?sponsors@techcrunch.com. We’ll see you soon, New York!Source: http://feedproxy.google.com/~r/Techcrunch/~3/-ythgXbd888/
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New agent might control breast-cancer growth and spread
Apr. 22, 2013 ? A new study led by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) suggests that an unusual experimental drug can reduce breast-cancer aggressiveness, reverse resistance to the drug fulvestrant and perhaps improve the effectiveness of other breast-cancer drugs.
The findings of the laboratory and animal study, published in the Journal of Experimental Medicine, suggest a new strategy for treating breast cancer, the researchers say.
The drug, called AS1411, belongs to a class of agents called G-rich aptamers. The agent works by blocking the cell's production of molecules called microRNA, some types of which are associated with cancer. Specifically, the drug inhibits a protein called nucleolin that plays a critical role in the microRNA maturation process.
MicroRNA molecules help cells control the amount and kinds of proteins they make, and abnormal levels of certain microRNAs are a hallmark of many cancers.
"This study of the role of nucleolin in micro RNA regulation has clear clinical implications," says principal investigator Dr. Carlo M. Croce, director of Ohio State's Human Cancer Genetics program and a member of the OSUCCC -- James Molecular Biology and Cancer Genetics program.
"It supports a novel treatment for breast cancer that reduces cancer aggressiveness and restores drug-sensitivity by inhibiting the processing of specific microRNAs that are highly expressed in cancers."
First author Flavia Pichiorri, assistant professor of hematology, notes that nucleolin is a promising therapeutic target for microRNA modulation in cancer cells.
"To our knowledge, this is the first large study to show a clear association between nucleolin and specific microRNAs that are causally involved in cancer," she says. "We also believe it is the first study to show that targeting nucleolin with a G-rich aptamer can control breast-cancer metastasis in an animal model through microRNA regulation."
The study's key technical findings include:
- Nucleolin is present at abnormally high levels in breast cancer cells.
- AS1411 reduces nucleolin levels and inhibits the processing of certain cancer-associated microRNAs, including miR-21, miR-103, miR-221 and miR-222, whose overexpression in breast cancer is associated with drug resistance and aggressiveness.
- AS1411 affects breast-cancer-cell motility and invasiveness by reducing the expression of several genes targeted by nucleolin-related microRNAs (e.g., PTEN);
- Impairing nucleolin in fulvestrant-resistant breast-cancer cells restores sensitivity to the drug, suggesting that agents targeting nucleolin can improve the effectiveness of conventional anti-cancer agents.
Funding from the NIH/National Cancer Institute (grants CA154200 and CA107106), the Kimmel Foundation and the Spielman Fund for Breast Cancer Research supported this research.
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Story Source:
The above story is reprinted from materials provided by Ohio State University Medical Center.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Flavia Pichiorri, Dario Palmieri, Luciana De Luca, Jessica Consiglio, Jia You, Alberto Rocci, Tiffany Talabere, Claudia Piovan, Alessandro Lagana, Luciano Cascione, Jingwen Guan, Pierluigi Gasparini, Veronica Balatti, Gerard Nuovo, Vincenzo Coppola, Craig C. Hofmeister, Guido Marcucci, John C. Byrd, Stefano Volinia, Charles L. Shapiro, Michael A. Freitas, and Carlo M. Croce. In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation. Journal of Experimental Medicine, 2013 DOI: 10.1084/jem.20120950
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/8oJ8W5WH99U/130422101137.htm
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Whoa, Computer Graphics Can Make Water Look Real Now
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95% Gimme The Loot
All Critics (40) | Top Critics (22) | Fresh (38) | Rotten (2)
A thousand-watt jolt of mischief, a spunky, funky, ebullient indie that packs its 81 minutes with cinematic exhilaration.
It may be a slight movie, but it has its sunny charms.
A movie about teenage taggers in the Bronx should be fast and raw, scruffy and loose, and Adam Leon's Gimme the Loot is just that.
As it lopes along, the movie offers a warm but very sharp portrait of New York's have-nots and their uneasy relationship with the haves.
"Gimme the Loot" shouldn't be as appealing and exuberant as it is, it really shouldn't.
Tashiana Washington and Ty Hickson are terrific in the main roles. So is Zo? Lescaze as Ginnie, a spoiled white kid who teaches the taggers a thing or two about drift and being dissolute.
Simultaneously real and hopeful, "Loot" has almost no plot, but when the setting is so fresh and the characters feel so raw and alive, who needs one?
Ghetto laughs with a sophisticated point of view.
...a magical, summery treat.
Promotes robbery and can't be serious in expecting us to care whether Malcolm and Sofia become more than friends.
The winner of the Indie Spirit 'One to Watch' award could never work again and will always have a memorable New York City film to his credit.
An impressive debut feature, Gimme the Loot is also an unusual take on characters who want to leave their stamp on "the city that never sleeps."
Much more grownup than it looks, Gimme the Loot is that rare teen-centric film whose brisk pace is unburdened by sentimentality.
Writer-director Adam Leon has crafted a classic New York story, a film imbued with the fast rhythms and muggy sensations of city life during the summer.
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Source: http://www.rottentomatoes.com/m/gimme_the_loot_2012/
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Sniffing out solutions for millions of Americans with smell loss
Apr. 21, 2013 ? Snot. It's not something most of us spend a lot of time thinking about, but, for a team of researchers in Washington, D.C., it's front and center.
Robert I. Henkin, founder of the Taste and Smell Clinic in is charmingly self-deprecating. He says with a chuckle that he's often called a "spit and snot doctor," but he knows all too well that for his patients -- those who no longer can appreciate the fragrance of fresh-cut grass or the intricacies of an herb-infused sauce -- such loss is no laughing matter.
"You might think: 'Oh well, you can still hear. You can still see.' But it's amazingly important to be able to taste and smell," Henkin says. "When you say 'hello' in (some parts of China), you don't say 'hello' -- you say 'Have you eaten yet?' In other words, the social aspects of being able to eat and enjoy that are critical, and to lose that -- you lose a significant part of life."
Henkin, who at the National Institutes of Health established the first clinical program to study taste and smell dysfunction, has spent the better part of his professional life trying to get the lay of the land when it comes to the fluids that contribute to those two senses. He and his team over the years have conducted countless experiments to figure out what makes up nasal mucus and saliva and how those components affect taste and smell.
"The thing to recognize is there are 21 million people in the United States who have some abnormality of smell function. That's an amazing number," says Henkin.
On Sunday, April 21, Henkin will present new research results at the Experimental Biology 2013 conference with the hope that attendees there also will take the mission seriously, build upon his findings and come up with new therapies for patients like his.
Henkin's newest work describes the concentrations of cytokines, molecules involved in cell signaling, in nasal mucus. He'll present his findings at the annual meeting of the American Society for Biochemistry and Molecular Biology, which is being held in conjunction with the Experimental Biology 2013 conference.
"In a rather na?ve way, we went ahead and looked at these cytokines in nasal mucus because nobody's ever done it before," Henkin explains. This kind of strategy is par for the course for Henkin, who also was the first to report which proteins are present in saliva in 1978 and which proteins are present in nasal mucus in 2000. He emphasizes that "you can't understand the (disease) mechanisms unless you understand what's there."
"This whole role of nasal mucus -- what's there, how it works -- is something that (researchers) haven't really considered," he says. "It takes a dumb guy like me to go ahead and say 'OK, let's figure out what's there, and then we can see what we're going to do about it. It's a different approach."
What's so different about it? Henkin says most of his patients come to him as a last resort, because their primary physicians and even specialists can't offer any lasting solutions.
"The people who are interested in (smell loss) are primarily otolaryngologists, and they're trained as surgeons ? They're not trained to think about this" on the molecular level, Henkin says. "So they look at the nose, and if there's a polyp they'll take it out and say, 'Aha, there's the answer. We'll make the nasal cavity cleaner.' Well, these (molecular) structures in the nose that cause these problems are manifestations of some underlying disease process, which they've been trying to figure out for a while but haven't really succeeded."
Henkin's group has succeeded in restoring smell loss in many patients -- and sometimes by seemingly unconventional means. A few years back, they tested out a drug long used in asthmatics, theophylline, and they found that oral use could induce higher levels of a protein called cAMP in nasal mucus, which improved some patients' ability to smell. The team later found that administering a smaller dose intranasally produced a more profound effect.
Henkin says examples like that underscore the importance of understanding the molecular makeup of nasal mucus and the interactions within, rather than immediately turning to surgery or, another common practice, giving patients steroids.
"Because they've used these (steroids) to inhibit polyp formation in the nose, what happens is that in some people the smell comes back for a limited period of time. It may come back for a day or a week. And then when the drug wears off, they can't smell again," Henkin says. "We now understand a little bit about how that works -- how it affects those cytokines and other substances."
Cytokines are molecules that deliver information and induce some kind of response -- usually during immunological and inflammatory processes. Henkin's team found that in nasal mucus of patients with smell loss the concentration of anti-inflammatory cytokines was much higher than the concentrations of pro-inflammatory cytokines . This balance is important, he says, because the cytokine interleukin-6, which is pro-inflammatory, was particularly abundant.
"We'd looked at the literature and recognized that IL-6 is obviously elevated in a number of inflammatory diseases, such as rheumatoid arthritis. As a matter of fact, with rheumatoid arthritis you commonly have smell loss," Henkin says. "We're trying to make these connections, you see, and understand the relationships in these underlying interactions -- to give people some idea (about) homeostasis in the nasal cavity, how it's occurring, what's in nasal mucus and how each of these substances plays a specific role in smell function."
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Story Source:
The above story is reprinted from materials provided by American Society for Biochemistry and Molecular Biology (ASBMB), via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/5N55NUeUWDw/130421151622.htm
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Monday, April 22, 2013
No light at end of tunnel yet for euro zone
By Alan Wheatley, Global Economics Correspondent
LONDON (Reuters) - An early peek this week at how the euro zone economy performed in April could cement the case for the next installment in an unprecedented campaign of monetary easing by the world's major central banks.
A preliminary survey of purchasing executives from the 17-country bloc is likely to furnish the new evidence of economic weakness that Jens Weidmann, the president of Germany's hard-line central bank, says is needed for the European Central Bank to cut interest rates.
The composite index derived from the survey by data providers Markit is likely to be unchanged at 46.5, well below the 50 threshold denoting expansion.
The euro zone economy, in short, remains dead in the water.
"We need more monetary stimulus. What that means to me is lower interest rates," said Mark Zandi, chief economist at Moody's Analytics.
Weidmann is among those who believe the ECB's exact stance matters less than the fact that monetary policy is not being transmitted to all corners of the euro zone.
Borrowing costs on the struggling southern rim are thus much higher than in countries at the euro's core.
Zandi agreed that cutting the ECB's main 0.75 percent policy rate would not revive lending by banks, which badly needed strengthening. But lower interest rates would weaken the euro.
That would help exports, especially in Germany, which in turn was key to preserving popular support for emergency measures to stop the euro from breaking up, Zandi argued.
"The most important thing for keeping the euro zone together in the very near term is to make sure that the German economy remains solid and that unemployment remains low. You need the German population to be committed to the euro zone," he said.
EXPORT HEADWINDS
Germany's export-orientated economy has held up better than most of its euro zone peers, but a monthly business survey by the Munich IFO economics institute is likely to show a dip, according to economists polled by Reuters.
"When you look at the latest signals from China and the United States, the export growth prospects of German companies have deteriorated significantly," said Tobias Blattner, an economist with Daiwa Capital Markets in London.
As such, the ECB would be paying close attention to the latest purchasing managers' indexes not just from the euro zone but from the bloc's main partners. On a trade-weighted basis, these have fallen in the past couple of months.
Blattner expects a rate cut at May's ECB meeting. Although most ECB policymakers doubt it would make much difference, he said the symbolism would fan expectations of additional, less conventional steps to spur lending to the periphery.
"They all know that it needs to be accompanied, at the same time or possibly a month later, by some further non-standard measures," he said. "That's important. You cut rates and people say the next step must be something that will have an impact."
QUESTION MARKS OVER U.S. GROWTH
A pair of unexpectedly soft regional Federal Reserve surveys last week reinforced the view that yet another spring slowdown - the fourth in as many years - is unfolding in the United States.
That prospect is likely to take the shine off what promises to be a robust first-quarter GDP report on Friday.
Economists polled by Reuters expect the economy to have expanded at a 3.0 percent clip, up from 0.4 percent in the last three months of 2012, despite the drag of higher payroll taxes and looming across-the-board cuts in federal spending.
The consensus on Wall Street is for full-year growth of around 2 percent, but Jason Ware, chief analyst at Albion Financial Group in Salt Lake City, is penciling in an outcome closer to 2.5 percent.
"The economic pick-up, combined with sustainable gains in housing and business investment, should help propel the expansion through these government budget cuts that we're going to be dealing with," he said.
After a puny 88,000 increase in non-farm jobs in March, Ware expects the monthly pace of hiring to climb back to a range of 150,000 to 200,000.
The other big U.S. growth driver will be housing. The annual rate of housing starts jumped 7 percent in March to more than 1 million - a figure Ware called 'mind-boggling' given the depths from which the market is recovering - and sales of both new and existing homes are expected to post increases this week.
"Hiring and housing is the story so far," Ware said. "Those two events together help to repair household finances and that makes us reasonably sanguine about the outlook for the rest of the year."
(Editing by Toby Chopra)
Source: http://news.yahoo.com/no-light-end-tunnel-yet-euro-zone-190208945--business.html
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Artistic Wedding Films: Newport Hyatt Same Day Edit Film // Luke ...
This wedding has a much more special meaning than most weddings, my industry colleague and good friend Luke was married yesterday to his love, Jen and I was there to stand by his side and witness it. Yea-up, no shooting for me on this day, I was a groomsmen and it was fun! The wedding took place at the Newport Hyatt Regancy in Newport, RI. The weather was a concern in the morning, but the skies cleared and the plan for an outdoor ceremony in front of the Lighthouse was a go! So many of the industries' best played a part in making this wedding special, memorable and fun filled!
I am very lucky and so is Luke & Jen, because I have a fabulous and talented team! ?Crystal lead the team to capture a perfect film and she was helped by Chris, Neal and Myles. ?Besides turning on the Time-lapse GoPro and charging a few batteries, I was there to enjoy and I was in full trust of this great team! ?Not only did they do an amazing job of shooting the day, they allowed Crystal to produce another amazing Same Day Edit for the bride and groom and their family and friends to enjoy! ?As always, the SDE was a success and a great hit! ?See it for yourself and you be the judge!
- F. Mike
Cinematography: Artistic Wedding Films
Event Filmmakers: Crystal, Chris, Neal & Myles
SDE Editor: C. Burns
Venue: Newport Hyatt
Planning: Details with Love, Kristin Love
Entertainment:
DJ & MC: Luke Renchan Entertainment, Tony
Live Band: Felix Brown Band
Cake: Creative Cake Co, Karen Benjamin
Decor / Shears: Exquisite Events
Floral Designs: Golden Gate Studios
Lighting: Luke Renchan Entertainment
Photography: Sara Zarella Photography
Popcorn / Candy Girls: Infinite Events
Expresso Bar / Italian Cookies: Only the Finest Italian Cookies
Rentals: Rentals Unlimited
Tuxedos: Anthony's House of Formals
Dress: Helene's Bridal
Here was Crystal working on the Same Day Edit, the pressure was on!
Source: http://artisticweddingfilms.blogspot.com/2013/04/lukeandjensde.html
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